|
KMID : 1003219980040010086
|
|
Journal of Korean Oriental Chronic Disease
1998 Volume.4 No. 1 p.86 ~ p.97
|
|
|
Studies on the Antiallergic Effect of RADIX ASARI
|
|
|
|
|
Abstract
|
|
|
|
This study was investigated the inhibitory activity of RADIX ASARI (RA) on type Ⅰ immediate hypersensitivity of the anaphylactic type. RA inhibited compound 48/80 -induced anaphylaxis 100% with a dose of 0.5g/㎏ body weight at 1 h before or 5 and 10 min after injection of compound 48/80. RA also exhibited the dose-dependent inhibitory effect on compound 48/80-induced, substance-p-induced and anti-DNP IgE-induced histamine release from rat peritoneal mast cells. Moreover, it was clearly demonstrated that RA and disodium cromoglycate disodium cromoglycate potently inhibited such type Ⅰ allergic reactions as anaphylactic shocks, suggesting that these drugs, at least in part, share the same mechanism of action. It is suggested that RA may exert a stronger inhibition on the mast cell degranulation process. When I examined the effect of RA on the release of IgE in the mouse spleen whole cells and human myeloma U266131, the release of IgE is inhibited by RA. Stimulation of RBL-2H_3 cells with anti-DNP IgE for 16hr induced the expression of TNF-α mRNA but RA decreased TNF-α mRNA expression. These results suggest the possibility that RA-induced inhibition of type Ⅰ allergic reaction is regulated by histamine, IgE and TNF-α.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|